Real Madrid will do battle with their city rivals Atletico Madrid in the Champions League semi-finals.
Sid Lowe explains why few managers have made as big an impact at a club as Diego Simeone at Atletico Madrid.
"In theory it's better to play the return leg at home but that all depends on the result of the first leg".
The draw on Friday pitted Juventus and Monaco in the other semifinal.
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The 39-year-old Buffon said that Atletico, who would dearly love revenge over Real in the final in Cardiff, might have an edge over the other three teams because they are out of the La Liga title race so can rest players for Europe.
It is a tantalising clash of thrilling young talent and practised, battleworn heads: Monaco will hope to get their first semifinal since 2004, when they won the competition, off to a good start in the home leg, but Juventus - seeking their first Champions League triumph since 1996 - may feel confident of keeping them at arm's length.
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Now, all eyes turn to semi-final as these four teams still involved in 2016/2017 UEFA Champions League found out their opponents in the Champions League final four.
Monaco had enjoyed a comfortable 6-3 aggregate win over Borussia Dortmund in the quarters, and will be the underdogs going into their tie against Juventus.
With United now four points outside the Premier League top four, winning the Europa League for the first time may represent their best chance of qualifying for the Champions League. It won a record-extending 11th title last season.
And in teenage striking sensation Kylian Mbappe, 18, allied with a rejuvenated Radamel Falcao, they have the firepower to trouble any defence.
The French side are full of attacking vim and have hit a staggering 141 goals in all competitions this season.
Zinedine Zidane's side could become the first club to retain the trophy in the Champions League era in the final on 3 June in Cardiff.