The GBU-43/B Massive Ordnance Air Blast bomb - better known as the "mother of all bombs" - hit IS hideouts in Achin district in eastern Nangarhar province.
The Office of the President, ARG Palace, in a statement, said the followers of the dreaded terrorist group suffered heavy casualty, while confirming the close coordination between Afghan and American forces to destroy the caves, Khama Press reports.
The site where the "mother of all bombs" was dropped on an ISIS complex in Afghanistan.
The U.S. military headquarters in Kabul said in a statement that the bomb was dropped at 7:32 p.m. local time Thursday on a tunnel complex in Achin district of Nangarhar province, where the Afghan affiliate of ISIS has been operating.
President Donald Trump said Thursday the bombing was "another successful job". "The decision to drop the MOAB in eastern Afghanistan sends a clear message that the U.S. is committed and determined to defeating ISIS and other terrorist organisations in Afghanistan", said Senator Jim Inhofe, senior member of the Senate Armed Services Committee.
"But I think, also, President Trump must have decided: 'Yes, get on and do it, because it is consistent with the message I want to send to the rest of the world'". Nicholson said the strike was created to minimize the risk to Afghan and USA forces conducting clearing operations in the Achin area "while maximizing the destruction" of IS fighters and facilities.
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Nangarhar, which borders Pakistan, is a hotbed of IS militancy. This munition was developed during the Iraq War. It is a large, powerful and accurately delivered weapon.
In its second major display of military might in one week, the United States dropped its most powerful non-nuclear bomb on ISIS positions in a remote part of Afghanistan.
"Although the MOAB weapon leaves a large footprint, it is discriminate and requires a deliberate launching toward the target", the review said, adding, "It is expected that the weapon will have a substantial psychological effect on those who witness its use".
Afghan officials said 36 fighters loyal to Islamic State were killed.
The GPS-guided explosive was dropped via an Lockheed MC-130 transport plane.
Former US state department spokesman PJ Crowley told BBC Radio 4's Today programme the use of the weapon was an indication of how Mr Trump had given "greater leeway to the military in terms of what it can do" in Afghanistan and Syria. "US forces will continue offensive operations until ISIS-K (IS) is destroyed in Afghanistan", it said.