And despite persistent concerns over teens and young adults abusing drugs, middle-aged adults were the most likely to suffer a fatal overdose, according to the report.
The states with the highest rate of drug overdose deaths in 2015 were West Virginia, New Hampshire, Kentucky and Ohio.
Here are some statistics from the Centers for Disease Control report.
While the number of heroin-related deaths quadrupled from 2010 to 2015, the percentage share of all overdose deaths that were related to heroin tripled, from 8 percent to 25 percent.
Heroin-related deaths in the U.S. skyrocketed in the span of five years, amounting to a quarter of all overdose deaths by 2015, according to new federal data, presenting another grim snapshot of America's opioid epidemic. Additionally, researchers discovered the rate of fatal drug overdoses has doubled since 1999. More than 33,000 people died from opioids in 2015, and the CDC noted almost 500,000 people between 2000 to 2015 have suffered related deaths. The new report "highlights an ongoing problem in that area", she told Live Science. But the rate grew the fastest - an average of 10.5 percent per year from 1999 to 2015 - among adults between 55 and 64 years old. In 2015, adults aged 45 to 54 had the highest death rate from drug overdose at 30 deaths per 100,000.
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During the 16-year study period, the rate of overdose deaths among white people almost quadrupled, from 6 deaths per 100,000 people in 1999 to 21 deaths per 100,000 people in 2015.
Although the percentage of overdose deaths from heroin is rising, the percentage of deaths from some types of prescription opioids, including oxycodone and hydrocodone, has declined slightly, dropping from 29 percent of all drug overdose deaths in 2010 to 24 percent in 2015, the report said.
The data suggested a shift away from overdose deaths caused by opioid painkillers. The percentage of overdose deaths from methadone also dropped during this period, decreasing from 12 percent of drug overdose deaths in 2010 to 6 percent in 2015.
Generation X and baby boomer had the biggest jump in deaths from drug overdoses. Heroin's increase was met with decreases in drug deaths including oxycodone and methadone.
The states with the highest rates were: West Virginia, with 41.5 per 100,000; New Hampshire, with 34.3; and Kentucky and OH each with 29.9.